{"id":5337,"date":"2019-04-30T08:31:26","date_gmt":"2019-04-30T07:31:26","guid":{"rendered":"https:\/\/www.repromeda.rs\/?p=5337"},"modified":"2019-04-30T08:31:26","modified_gmt":"2019-04-30T07:31:26","slug":"ponovljeno-apsolviranje-embriotransfera-bez-detaljnih-ispitivanja-nema-smisao-resenje-je-pgt-a","status":"publish","type":"post","link":"https:\/\/www.repromeda.rs\/?p=5337","title":{"rendered":"Ponovljeno apsolviranje embriotransfera bez detaljnih ispitivanja nema smisao. Re\u0161enje je PGT-A."},"content":{"rendered":"

Ako ste nekada imali poba\u010daj, \u017eelite samo jedno \u2013 da se nikada ne ponovi. Ponovljeni poba\u010daji nisu uredu i uvek je potrebno da se istra\u017ei njihov razlog. Uz pomo\u0107 preimpletacijskog genetskog testiranja aneuploidija je mogu\u0107e da se sni\u017ei rizik poba\u010daja, kao i rizik komplikacija u trudno\u0107i ili ro\u0111enja deteta sa defektom, ali ba\u0161 suprotno da se pove\u0107a\u00a0 uspe\u0161nost ve\u0161ta\u010dke oplodnje.<\/em><\/p>\n

\u0160ta su aneuploidije? Da li mogu da uti\u010du na pravilno ka\u010denje embriona?<\/h2>\n

Situacija kada se kod embriona pojavljuje dodatan hromozom ili obrnuto, kada neki hromozom nedostaje, naziva se aneuploidija<\/strong>. Takve mane hromozoma koji nastaju nasumi\u010dno tokom zrenja jajne \u0107elije, sperme ili tokom razvoja embriona, se mogu pojaviti i kod para koji nemaju prethodne genetske komplikacije. Tako u pore\u0111enju sa preimplatacijskim genetskim testiranjem monogenih oboljenja<\/a> (PGT-M), koje proverava konkretne nasledne mane, PGT-A<\/strong> odre\u0111uje novonastale. Obe metode omogu\u0107avaju da se zna\u010dajno sni\u017ee rizici uro\u0111enih mana.<\/p>\n

Aneuploidan embrion<\/strong> se u telu \u017eene mo\u017ee zaka\u010diti, ali takva trudno\u0107a se zavr\u0161ava poba\u010dajem ili ro\u0111enjem deteta sa defektom ili na primer Daunovim sindromom<\/strong> (dodatan hromozom 21), Edvardovim sindromom<\/strong> (dodatan hromozom 18) ili Pataunov sindromom<\/strong> (dodatan hromozom 13).<\/p>\n

U kojim slu\u010dajevima je potrebno testiranje embriona?<\/h2>\n

Pored ponovljenih poba\u010daja postoje i dalji objektivni razlozi zahvaljuju\u0107i kojima je dobro re\u0161enje PGT-A<\/strong>. Ovde na primer mo\u017ee da se ubroje i ponovljeni neuspe\u0161ni transferi embriona u prethodnim IVF ciklusima, ro\u0111enje deteta sa razvojnom manom, lo\u0161i parametri spermiograma partnera, stanja posle le\u010denja onkolo\u0161kih oboljenja pomo\u0107u hemoterapije ili zra\u010denjem.<\/p>\n

Ako imate 35 ili vi\u0161e godina, ispitivanje va\u0161ih embriona je veoma opravdano. Na osnovu poslednjih ispitivanja su ba\u0161 poreme\u0107aji brojnosti hromozoma kod \u017eena sa ve\u0107im brojem godina razlog za nagli pad plodnosti.<\/p>\n

O tome dali kod vas postoji odre\u0111eni rizik koji bi mogao da vam uslovi broj ili tok trudno\u0107e i da li je bolje da se embrioni ispitaju, mo\u017ee da vas informi\u0161e i novi test PANDA (panelska dijagnosti\u010dka analiza)<\/a>. Ovaj panel vam pored ostalog mo\u017ee re\u0107i da li ste sa partnerom genetski i reproduktivno kompatibilni i da li vam se tako bez komplikacija mo\u017ee roditi zdravo dete.<\/p>\n

Kako se PGT-A sprovodi i \u0161ta mu prethodi?<\/h2>\n

Embriolozi oplo\u0111uju jajne \u0107elije spermatozoidima iz kojih nastaju embrioni. Tokom narednih 5-6 dana se dalje brinu mere\u0107i njihov kvalitet i pravilan razvoj. \u010cim su embrioni u pravilnom stanju razvoja, odnosno u stanju blastociste<\/strong>, izvodi se biopsija<\/strong> (odabir nekoliko \u0107elija). Te \u0107elije su potom testirane uz pomo\u0107 aparata MiSeq<\/strong>, koji omogu\u0107ava skeniranje hiljada delova DNK i odre\u0111ivanje genetskih mutacija. Najperspektivniji embrioni sa normalnim brojem hromozoma se potom zamrzavaju i u nekom od daljih ciklusa Vam se jedno od njih transferuje.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Ako ste nekada imali poba\u010daj, \u017eelite samo jedno \u2013 da se nikada ne ponovi. Pro\u010ditajte vi\u0161e<\/a><\/p>\n","protected":false},"author":5,"featured_media":5338,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,1],"tags":[],"acf":[],"yoast_head":"\nPonovljeno apsolviranje embriotransfera bez detaljnih ispitivanja nema smisao. Re\u0161enje je PGT-A.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.repromeda.rs\/?p=5337\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ponovljeno apsolviranje embriotransfera bez detaljnih ispitivanja nema smisao. 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